Pancreatic Stellate Cells (PSCs) express Cyclooxygenase-2 (COX-2) and pancreatic cancer stimulates COX-2 in PSCs
نویسندگان
چکیده
منابع مشابه
direct sequencing of cyclooxygenase-2 (cox-2) revealed an intronic variant rs201231411 in iranian patients with pancreatic cancer
background there are hoarding documents for the biological importance of cyclooxygenase-2 (cox-2) in pancreatic carcinogenesis. we aimed to thoroughly investigate the dna sequence variations of whole cox-2 exons in a large case-control study of pancreatic cancer by direct sequencing. methods the entire exonic regions of cox-2 including 10 exons were sequenced in the germline dna of 96 patient...
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Cyclooxygenase 2 (COX-2) inhibitors are promising antiangiogenic agents in several preclinical models. The aim of the present study was to evaluate the effect of selective COX-2 inhibitors on vascular endothelial growth factor (VEGF) production in vitro and angiogenesis and growth of pancreatic cancer in vivo, focusing on putative differences between COX-2-negative and COX-2-positive tumors. VE...
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OBJECTIVE Eighty percent of pancreatic ductal adenocarcinomas (PDAs) overexpress mucin 1 (MUC1), a transmembrane mucin glycoprotein. MUC1(high) PDA patients also express high levels of cyclooxygenase 2 (COX-2) and show poor prognosis. The cytoplasmic tail of MUC1 (MUC1-CT) partakes in oncogenic signaling, resulting in accelerated cancer progression. Our aim was to understand the regulation of C...
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COX-2 is upregulated in pancreatic ductal adenocarcinomas (PDAC). However, how COX-2 promotes PDAC development is unclear. While previous studies have evaluated the efficacy of COX-2 inhibition via the use of nonsteroidal anti-inflammatory drugs (NSAID) or the COX-2 inhibitor celecoxib in PDAC models, none have addressed the cell intrinsic versus microenvironment roles of COX-2 in modulating PD...
متن کاملCyclooxygenase-2 (COX-2): a molecular target in prostate cancer.
Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, COX-2 expression may be a universal phenomenon. In general, COX-2 is up-regulated throughout the tumorigenic process, from early hyperplasia to metastatic disease. COX-2 has been reported ...
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ژورنال
عنوان ژورنال: Molecular Cancer
سال: 2005
ISSN: 1476-4598
DOI: 10.1186/1476-4598-4-27